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Article

Error-prone polymerase activity causes multinucleotide mutations in humans.

Genome research - 1 Sept 2014

Harris Kelley, Nielsen Rasmus

Abstract excerpt

About 2% of human genetic polymorphisms have been hypothesized to arise via multinucleotide mutations (MNMs), complex events that generate SNPs at multiple sites in a single generation. MNMs have the potential to accelerate the pace at which single genes evolve and to confound studies of demography and selection that assume all SNPs arise independently. In this paper, we examine clustered mutations that are...

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Identifiers

PMID: 25079859
DOI: 10.1101/gr.170696.113
PMCID: PMC4158752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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