Article
Lagging-strand replication shapes the mutational landscape of the genome.
Nature - 26 Feb 2015
Reijns Martin A M, Kemp Harriet, Ding James, de Procé Sophie Marion, Jackson Andrew P, Taylor Martin S
Abstract excerpt
The origin of mutations is central to understanding evolution and of key relevance to health. Variation occurs non-randomly across the genome, and mechanisms for this remain to be defined. Here we report that the 5' ends of Okazaki fragments have significantly increased levels of nucleotide substitution, indicating a replicative origin for such mutations. Using a novel method, emRiboSeq, we map the genome-wide...
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