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Article

DNA replication timing and higher-order nuclear organization determine single-nucleotide substitution patterns in cancer genomes.

Nature communications - 1 Jan 2013

Liu Lin, De Subhajyoti, Michor Franziska

Abstract excerpt

Single-nucleotide substitutions are a defining characteristic of cancer genomes. Many single-nucleotide substitutions in cancer genomes arise because of errors in DNA replication, which is spatio-temporally stratified. Here we propose that DNA replication patterns help shape the mutational landscapes of normal and cancer genomes. Using data on five fully sequenced cancer types and two personal genomes, we...

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Identifiers

PMID: 23422670
DOI: 10.1038/ncomms2502
PMCID: PMC3633418

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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