Article

Engineered basement membrane mimetic hydrogels to study mammary epithelial morphogenesis and invasion

2025-03-03

Abstract excerpt

Reconstituted basement membrane (rBM) products like Matrigel are widely used in 3D culture models of epithelial tissues and cancer. However, their utility is hindered by key limitations, including batch variability, xenogenic contaminants, and a lack of tunability. To address these challenges, we engineered a 3D basement membrane (eBM) matrix by conjugating defined extracellular matrix (ECM) adhesion peptides (IKV...

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Literature Corpus work: 930556b7-5b6b-5404-bd6e-f0a715e7c481
DOI: 10.1101/2025.02.28.640825

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