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Programming temporal stiffness cues within extracellular matrix hydrogels for modelling cancer niches

16 Feb 2024

Abstract excerpt

Extracellular matrix (ECM) stiffening is a common occurrence during the progression of many diseases, such as breast cancer. To accurately mimic the pathophysiological context of disease within 3D in vitro models, there is high demand for smart biomaterials which replicate the dynamic and temporal mechanical cues of diseased states. This study describes a preclinical disease model, using breast cancer as an...

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PMID: 38420142
DOI: 10.1016/j.mtbio.2024.101004

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