Article
Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium.
Nature materials - 1 Oct 2014
Chaudhuri Ovijit, Koshy Sandeep T, Branco da Cunha Cristiana, Shin Jae-Won, Verbeke Catia S, Allison Kimberly H, Mooney David J
Abstract excerpt
In vitro models of normal mammary epithelium have correlated increased extracellular matrix (ECM) stiffness with malignant phenotypes. However, the role of increased stiffness in this transformation remains unclear because of difficulties in controlling ECM stiffness, composition and architecture independently. Here we demonstrate that interpenetrating networks of reconstituted basement membrane matrix and...
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