Article

Small extracellular vesicles promote stiffness-mediated metastasis

2023-07-02

Abstract excerpt

<h4>Summary</h4> Tissue stiffness is a critical prognostic factor in breast cancer and is associated with metastatic progression. Here we show an alternative and complementary hypothesis of tumor progression whereby physiological matrix stiffness affects the quantity and protein cargo of small EVs produced by cancer cells, which in turn drive their metastasis. Primary patient breast tissue produces significantly...

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Identifiers and source

Literature Corpus work: aeb86806-8a8d-529f-bf0c-870f707818ee
DOI: 10.1101/2023.07.01.545937

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