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Article

Hybrid Scaffolds Decouple Biochemical & Biophysical Regulation of Cell Phenotype.

Advanced healthcare materials - 1 Mar 2026

Song Xinyuan, Mitchell Samantha C, Smart Abbie N, Hardiman William, Bax Daniel V, Staley Ceri E, Probert Catherine, Collier Pamela, Meakin Marian, Ritchie Alison A, Mendonca Tania, Wright Amanda J, James Victoria, Grabowska Anna M, Merry Catherine L R, Best Serena M, Cameron Ruth E, Ashworth Jennifer C

Abstract excerpt

The extracellular matrix changes dramatically during the progression of diseases like cancer. These complex, tissue-specific changes are not adequately replicated by most current biomaterial disease models. This work demonstrates, for the first time, a biomaterial system allowing combined, independent control over stiffness, extracellular matrix composition and 3D collagen architecture. Defined hydrogel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41355234
DOI: 10.1002/adhm.202504086
PMCID: PMC12973354

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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