Article

Hybrid Scaffolds Decouple Biochemical & Biophysical Regulation of Cell Phenotype

2025-06-17

Abstract excerpt

The extracellular matrix changes dramatically during the progression of diseases like cancer. These complex, tissue-specific changes are not adequately replicated by most current biomaterial disease models. Here we demonstrate, for the first time, a biomaterial system allowing combined, independent control over stiffness, composition and 3D collagen architecture. We demonstrate successful perfusion of defined hydr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f02cc039-d225-5df3-bd14-f853351f73c2
DOI: 10.1101/2025.06.12.659085

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hybrid Scaffolds Decouple Biochemical & Biophysical Regulation of Cell PhenotypeDOI 10.1101/2025.06.12.659085Read

Hybrid Scaffolds Decouple Biochemical & Biophysical Regulation of Cell Phenotype.Semantic proximity Read

Programming temporal stiffness cues within extracellular matrix hydrogels for modelling cancer nichesSemantic proximity Read

Physical network regimes of 3D fibrillar collagen networks trigger invasive phenotypes of breast cancer cells.Semantic proximity Read

The Impact of the Local Mechanical Environment on Cell Shape and Chondrogenesis of Mesenchymal Stromal Cells in 3D Biomimetic Composite MaterialsSemantic proximity Read

Elucidating the combinatorial effect of substrate stiffness and surface viscoelasticity on cellular phenotype.Semantic proximity Read

Dynamic hybrid-hydrogel lung models decouple matrix composition, stiffness, and fibroblast memory to define distinct drivers of fibrotic progressionSemantic proximity Read

Mechanoregulation of Cancer-Associated Fibroblast Phenotype in Three-Dimensional Interpenetrating Hydrogel NetworksSemantic proximity Read

Matrix compliance regulates cellular and nuclear confinement of fibroblasts in tunable protein-based hydrogel microenvironmentsSemantic proximity Read

Tunable synthetic extracellular matrices to investigate breast cancer response to biophysical and biochemical cuesSemantic proximity Read

Engineered basement membrane mimetic hydrogels to study mammary epithelial morphogenesis and invasionSemantic proximity Read

Tissue mimetic hyaluronan bioink containing collagen fibers with controlled orientation modulating cell morphology and alignmentSemantic proximity Read

Interpenetrating networks of fibrillar and amorphous collagen promote cell spreading and hydrogel stabilitySemantic proximity Read