Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanoregulation of Cancer-Associated Fibroblast Phenotype in Three-Dimensional Interpenetrating Hydrogel Networks

27 Nov 2018

Abstract excerpt

Tumor stromal residing cancer-associated fibroblasts (CAFs) are significant accomplices in the growth and development of malignant neoplasms. As cancer progresses, the stroma undergoes a dramatic remodeling and stiffening of its extracellular matrix (ECM). However, exactly how these biomechanical changes influence the CAF behavior and the functional paracrine crosstalk with the neighboring tumor cells in a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3D Printing in Biomedical Research
Share to Cancer Cells and Metastasis
Share to Cellular Mechanics and Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30480453
DOI: 10.1021/acs.langmuir.8b02649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanoregulation of Cancer-Associated Fibroblast Phenotype in Three-Dimensional Interpenetrating Hydrogel NetworksPMID 30480453Read ↗

Mechanotranscriptomic Profiling of Breast Cancer Cells Intravasated from Engineered MicrotumorsSemantic proximity Read ↗

Sp1 mechanotransduction regulates breast cancer cell invasion in response to multiple tumor-mimicking extracellular matrix cuesSemantic proximity Read ↗

Bioengineered Hydrogels Recapitulate Fibroblast Heterogeneity in CancerSemantic proximity Read ↗

Biophysical perspectives to understanding cancer-associated fibroblastsSemantic proximity Read ↗

Matrix-bound EGF promotes malignant phenotypes of breast cancer organoids in the biomimetic ECM of alginateSemantic proximity Read ↗

The 3D Collagen Network as a Determinant of Tumor Progression and Drug Delivery Efficiency in Breast AdenocarcinomaSemantic proximity Read ↗

Programming temporal stiffness cues within extracellular matrix hydrogels for modelling cancer nichesSemantic proximity Read ↗

Tenascin-C activation of lung fibroblasts in a 3D synthetic lung extracellular matrix mimicSemantic proximity Read ↗

Fibrous Matrix Architecture-Dependent Activation of Fibroblasts with a Cancer-Associated Fibroblast-like Phenotype.Semantic proximity Read ↗

Harnessing Extracellular Matrix Biology for Tumor Drug DeliverySemantic proximity Read ↗

The Extracellular Matrix: Composition, Function, Remodeling and Its Role in Tumorigenesis<i></i>Semantic proximity Read ↗

Distinct phenotypes of cancer cells on tissue matrix gel.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.