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Article

Dynamic extracellular matrix stiffening induces a phenotypic transformation and a migratory shift in epithelial cells.

Integrative biology : quantitative biosciences from nano to macro - 19 Jun 2020

Allen Shane C, Widman Jessica A, Datta Anisha, Suggs Laura J

Abstract excerpt

Soft tissue tumors, including breast cancer, become stiffer throughout disease progression. This increase in stiffness has been shown to correlate to malignant phenotype and epithelial-to-mesenchymal transition (EMT) in vitro. Unlike current models, utilizing static increases in matrix stiffness, our group has previously created a system that allows for dynamic stiffening of an alginate-matrigel composite...

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PMID: 32472133
DOI: 10.1093/intbio/zyaa012

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