Article
Spontaneous retrotranspositions in normal tissues are rare and associated with cell-type-specific differentiation
2019-01-31
Abstract excerpt
Activation of retrotransposons and their insertions into new genomic locations, i.e., retrotranspositions (RTs), have been identified in about 50% of tumors. However, the landscape of RTs in different, normal somatic cell types in humans remains largely unknown. Using single-cell whole-genome sequencing we identified 528 RT events, including LINE-1 (L1), and Alu, in 164 single cells and clones of fibroblasts, neur...
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Identifiers and source
- Literature Corpus work
- a8986ca2-b279-5dda-a609-aa649d5ab50a
- DOI
- 10.1101/536896