Article

TDP-43 regulates GAD1 mRNA splicing and GABA signaling in Drosophila brains

2021-04-16

Abstract excerpt

<h4>ABSTRACT</h4> Alterations in the function of the RNA-binding protein TDP-43 is largely associated with the pathogenesis of amyotrophic lateral sclerosis (ALS), a devastating disease of the human motor system that leads to motoneurons degeneration and reduced life expectancy by molecular mechanisms not well known. Regarding to that, we found that the expression levels of the glutamic acid decarboxylase enzyme...

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Literature Corpus work: 9249457f-b9ed-5387-9a82-8491b156f5e5
DOI: 10.1101/2021.04.16.440162

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