Article

Endogenous TDP-43 prevents retrotransposons activation through Dicer-2 activity and the RNA silencing machinery in Drosophila neurons

2019-04-10

Abstract excerpt

<h4>ABSTRACT</h4> The aberrant expression of retrotransposable elements (RTEs) was observed in different neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), a terminal disorder characterized by functional alterations in the small RNA-binding protein TDP-43, suggesting that these events might be connected. Using genome wide gene expression profiles, we detected RTEs highly upregulated in TDP-...

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Literature Corpus work: 51333f25-461d-5250-87c5-0c02f3ade8f5
DOI: 10.1101/604421

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