Article

Modelling dementia in <i>Drosophila</i> uncovers shared and specific targets of TDP-43 proteinopathy across ALS and FTD relevant circuits

2022-11-16

Abstract excerpt

<h4>ABSTRACT</h4> Amyotrophic lateral sclerosis (ALS) and fronto-temporal dementia (FTD) comprise a spectrum of neurodegenerative diseases linked to TDP-43 proteinopathy, which at the cellular level, is characterized by loss of nuclear TDP-43 and accumulation of cytoplasmic TDP-43 puncta that ultimately cause RNA processing defects including dysregulation of splicing, mRNA transport and translation. Complementing...

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Literature Corpus work: 525c0c13-778d-50b4-a224-53805dffbe05
DOI: 10.1101/2022.11.16.516763

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