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TDP-43 regulates GAD1 mRNA splicing and GABA signaling in Drosophila CNS

21 Sept 2021

Abstract excerpt

Alterations in the function of the RNA-binding protein TDP-43 are largely associated with the pathogenesis of amyotrophic lateral sclerosis (ALS), a devastating disease of the human motor system that leads to motoneurons degeneration and reduced life expectancy by molecular mechanisms not well known. In our previous work, we found that the expression levels of the glutamic acid decarboxylase enzyme (GAD1),...

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PMID: 34548578
DOI: 10.1038/s41598-021-98241-z

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