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Article

Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioural phenotypes that characterize ALS and FTLD.

Human molecular genetics - 1 Oct 2013

Diaper Danielle C, Adachi Yoshitsugu, Lazarou Luke, Greenstein Max, Simoes Fabio A, Di Domenico Angelique, Solomon Daniel A, Lowe Simon, Alsubaie Rawan, Cheng Daryl, Buckley Stephen, Humphrey Dickon M, Shaw Christopher E, Hirth Frank

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are neurodegenerative disorders that are characterized by cytoplasmic aggregates and nuclear clearance of TAR DNA-binding protein 43 (TDP-43). Studies in Drosophila, zebrafish and mouse demonstrate that the neuronal dysfunction of TDP-43 is causally related to disease formation. However, TDP-43 aggregates are also observed in glia...

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Identifiers

PMID: 23727833
DOI: 10.1093/hmg/ddt243
PMCID: PMC3766182

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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