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Major hnRNP proteins act as general TDP-43 functional modifiers both in Drosophila and human neuronal cells

16 May 2017

Abstract excerpt

Nuclear factor TDP-43 is known to play an important role in several neurodegenerative pathologies. In general, TDP-43 is an abundant protein within the eukaryotic nucleus that binds to many coding and non-coding RNAs and influence their processing. Using Drosophila, we have performed a functional screening to establish the ability of major hnRNP proteins to affect TDP-43 overexpression/depletion phenotypes....

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PMID: 28575377
DOI: 10.1093/nar/gkx477

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