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A <i>Drosophila</i> model for TDP-43 proteinopathy

26 Jan 2010

Abstract excerpt

Neuropathology involving TAR DNA binding protein-43 (TDP-43) has been identified in a wide spectrum of neurodegenerative diseases collectively named as TDP-43 proteinopathy, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD). To test whether increased expression of wide-type human TDP-43 (hTDP-43) may cause neurotoxicity in vivo, we generated transgenic flies expressing hTDP-43...

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Amyotrophic Lateral Sclerosis Research
Cholinesterase and Neurodegenerative Diseases
Parkinson's Disease Mechanisms and Treatments

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20133767
DOI: 10.1073/pnas.0913602107

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