Article

Codon-optimized TDP-43-mediated neurodegeneration in a Drosophila model for ALS/FTLD

2019-07-10

Abstract excerpt

<h4>ABSTRACT</h4> Transactive response DNA binding protein-43 (TDP-43) is known to mediate neurodegeneration associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). The exact mechanism by which TDP-43 exerts toxicity in the brains of affected patients remains unclear. In a novel Drosophila melanogaster model, we report gain-of-function phenotypes due to misexpression of...

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Literature Corpus work: 459ed013-389e-5b0a-97d5-be7e7fa38e90
DOI: 10.1101/696963

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