Article

Glutamic acid metabolism alterations, causes and consequences in ALS

2018-01-01

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is a progressive and fatal motor system disease that affects motoneurons causing paralysis and muscular atrophy. Recently, it has been discovered that defects in the protein TDP- 43 were present in most patients that suffer from ALS. Similar modifications in the Drosophila melanogaster conserved protein TBPH reproduced the motor symptoms observed in ALS patients, such as locomot...

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Literature Corpus work: 3db4cbbb-36eb-527e-9045-e1e678f327ed
DOI: 10.21954/ou.ro.0000e36c

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