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Article

Downregulation of glutamic acid decarboxylase in Drosophila TDP-43-null brains provokes paralysis by affecting the organization of the neuromuscular synapses.

Scientific reports - 29 Jan 2018

Romano Giulia, Holodkov Nikola, Klima Raffaella, Grilli Federica, Guarnaccia Corrado, Nizzardo Monica, Rizzo Federica, Garcia Rodolfo, Feiguin Fabian

Abstract excerpt

Amyotrophic lateral sclerosis is a progressive neurodegenerative disease that affects the motor system, comprised of motoneurons and associated glia. Accordingly, neuronal or glial defects in TDP-43 function provoke paralysis due to the degeneration of the neuromuscular synapses in Drosophila. To identify the responsible molecules and mechanisms, we performed a genome wide proteomic analysis to determine...

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Identifiers

PMID: 29379112
DOI: 10.1038/s41598-018-19802-3
PMCID: PMC5789004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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