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Drosophila Answers to TDP-43 Proteinopathies

18 Apr 2012

Abstract excerpt

Initially implicated in the pathogenesis of CFTR and HIV-1 transcription, nuclear factor TDP-43 was subsequently found to be involved in the origin and development of several neurodegenerative diseases. In 2006, in fact, it was reported for the first time the cytoplasmic accumulation of TDP-43 in ubiquitin-positive inclusions of ALS and FTLD patients, suggesting the presence of a shared underlying mechanism for...

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PMID: 22577517
DOI: 10.1155/2012/356081

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