Article

Retrotransposon Activation Contributes to Neurodegeneration in a <i>Drosophila</i> TDP-43 Model of ALS

2016-11-28

Abstract excerpt

<h4>ABSTRACT</h4> Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two incurable neurodegenerative disorders that exist on a symptomological spectrum and share both genetic underpinnings and pathophysiological hallmarks. Functional abnormality of TAR DNA-binding protein 43 (TDP-43), an aggregation-prone RNA and DNA binding protein, is observed in the vast majority of both famil...

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Literature Corpus work: 11de22df-3407-530f-b010-04ac82d61230
DOI: 10.1101/090175

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