Article

CNV Neurons Are Rare in Aged Human Neocortex

2018-04-21

Abstract excerpt

Megabase-scale somatic copy number variants (CNVs) alter allelic diversity in a subset of human neocortical neurons. Reported frequencies of CNV neurons range from ∼5% of neurons in some individuals to greater than 30% in other individuals. Genome-wide and familial studies implicitly assume a constant brain genome when assessing the genetic risk architecture of neurological disease, thus it is critical to determin...

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Literature Corpus work: 9246d59d-a21f-54e9-99f1-232e0140fcf0
DOI: 10.1101/303404

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