Article

Mapping the Complex Genetic Landscape of Human Neurons

2023-03-07

Abstract excerpt

When somatic cells acquire complex karyotypes, they are removed by the immune system. Mutant somatic cells that evade immune surveillance can lead to cancer. Neurons with complex karyotypes arise during neurotypical brain development, but neurons are almost never the origin of brain cancers. Instead, somatic mutations in neurons can bring about neurodevelopmental disorders, and contribute to the polygenic landscap...

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Literature Corpus work: 0828c614-63da-538b-89ce-0cf91bf6083c
DOI: 10.1101/2023.03.07.531594

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