Article
Perinatal Elimination of Genetically Aberrant Neurons from Human Cerebral Cortex
2024-10-09
Abstract excerpt
Human neurons are postmitotic and long-lived, requiring precise genomic regulation to maintain function over a lifetime. Normal neuronal function is highly dependent on gene dosage, with copy number variants (CNVs) and heterozygous point mutations associated with a host of neurodevelopmental and neuropsychiatric conditions [1–5]. Here, we investigated the landscape of somatic CNVs arising in fetal human brains, an...
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Identifiers and source
- Literature Corpus work
- 20c9b77f-ce8c-5a6d-a8c2-c51995554e76
- DOI
- 10.1101/2024.10.08.617159