Article

Somatic copy number variant load in neurons of healthy controls and Alzheimer’s disease patients

2022-05-24

Abstract excerpt

<h4>Background</h4> The possible role of somatic copy number variations (CNVs) in Alzheimer’s disease (AD) aetiology has been controversial. Although cytogenetic studies suggested increased CNV loads in AD brains, a recent single-cell whole-genome sequencing (scWGS) experiment, studying frontal cortex brain samples, found no such evidence. Here we readdressed this issue using lowcoverage scWGS on pyramidal neuron...

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Literature Corpus work: 0e3f051e-5dff-5d45-987d-764369188ff6
DOI: 10.1101/2022.05.20.492539

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