Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mapping recurrent mosaic copy number variation in human neurons.

Nature communications - 17 May 2024

Sun Chen, Kathuria Kunal, Emery Sarah B, Kim ByungJun, Burbulis Ian E, Shin Joo Heon, Weinberger Daniel R, Moran John V, Kidd Jeffrey M, Mills Ryan E, McConnell Michael J

Abstract excerpt

When somatic cells acquire complex karyotypes, they often are removed by the immune system. Mutant somatic cells that evade immune surveillance can lead to cancer. Neurons with complex karyotypes arise during neurotypical brain development, but neurons are almost never the origin of brain cancers. Instead, somatic mutations in neurons can bring about neurodevelopmental disorders, and contribute to the polygenic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mosaicism

Share to Neurons

Source

Open in PubMed Open full text

Identifiers

PMID: 38760338
DOI: 10.1038/s41467-024-48392-0
PMCID: PMC11101435

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mapping recurrent mosaic copy number variation in human neurons.PMID 38760338Read ↗

Mapping the Complex Genetic Landscape of Human NeuronsSemantic proximity Read ↗

CNV Neurons Are Rare in Aged Human NeocortexSemantic proximity Read ↗

Perinatal Elimination of Genetically Aberrant Neurons from Human Cerebral CortexSemantic proximity Read ↗

Somatic mutation in single human neurons tracks developmental and transcriptional history.Semantic proximity Read ↗

Combined somatic mutation and transcriptome analysis reveals region-specific differences in clonal architecture in human cortex.Semantic proximity Read ↗

The Complete Genome Sequences, Unique Mutational Spectra, and Developmental Potency of Adult Neurons Revealed by Cloning.Semantic proximity Read ↗

Genomic mosaicism in the developing and adult brainSemantic proximity Read ↗

Somatic copy number variants in neuropsychiatric disorders.Semantic proximity Read ↗

Cell-type-resolved mosaicism reveals clonal dynamics of the human forebrain.Semantic proximity Read ↗

Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements.Semantic proximity Read ↗

Gene copy number variation and common human disease.Semantic proximity Read ↗

MONTAGE: a new tool for high-throughput detection of mosaic copy number variation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.