Article

Asynchronous structural rearrangements govern constriction of the human nuclear pore complex

2026-08-01

Abstract excerpt

The nuclear pore complex (NPC) is responsible for transport between the cytoplasm and nucleus. CryoET experiments have resolved multiple conformations of the pore that are dilated or constricted. Since the dilation state will impact transport properties, there is much interest in understanding the energetic factors that regulate dilation/constriction. To this end, we applied a structure-based (Gō-like) model to st...

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Literature Corpus work: 91b6dd0f-c5da-55df-9899-2a3d7e5c3b46
DOI: 10.64898/2026.07.31.742064

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