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Article

Simple rules for passive diffusion through the nuclear pore complex.

The Journal of cell biology - 10 Oct 2016

Timney Benjamin L, Raveh Barak, Mironska Roxana, Trivedi Jill M, Kim Seung Joong, Russel Daniel, Wente Susan R, Sali Andrej, Rout Michael P

Abstract excerpt

Passive macromolecular diffusion through nuclear pore complexes (NPCs) is thought to decrease dramatically beyond a 30-60-kD size threshold. Using thousands of independent time-resolved fluorescence microscopy measurements in vivo, we show that the NPC lacks such a firm size threshold; instead, it forms a soft barrier to passive diffusion that intensifies gradually with increasing molecular mass in both the...

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Identifiers

PMID: 27697925
DOI: 10.1083/jcb.201601004
PMCID: PMC5057280

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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