Article
Translocation through the nuclear pore complex: selectivity and speed by reduction-of-dimensionality.
Traffic (Copenhagen, Denmark) - 1 May 2005
Peters Reiner
Abstract excerpt
Translocation through the nuclear pore complex (NPC), a large transporter spanning the nuclear envelope, is a passive, diffusion-driven process, paradoxically enhanced by binding. To account for this mystery, several models have been suggested. However, recent experiments with modified NPCs make reconsideration necessary. Here, we suggest that nuclear transport receptors (NTRs) such as the karyopherins, in...
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