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Migration through a small pore disrupts inactive chromatin organization in neutrophil-like cells

26 Nov 2018

Abstract excerpt

BACKGROUND: Mammalian cells are flexible and can rapidly change shape when they contract, adhere, or migrate. The nucleus must be stiff enough to withstand cytoskeletal forces, but flexible enough to remodel as the cell changes shape. This is particularly important for cells migrating through confined spaces, where the nuclear shape must change in order to fit through a constriction. This occurs many times in the...

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PMID: 30477489
DOI: 10.1186/s12915-018-0608-2

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