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Article

Ion permeation through a narrow cavity constriction in KCNQ1 channels: Mechanism and implications for pathogenic variants.

Proceedings of the National Academy of Sciences of the United States of America - 17 Dec 2024

Mkrtchyan Liana, Sahakyan Harutyun, Eldstrom Jodene, Karapetyan Tatev, Abrahamyan Astghik, Nazaryan Karen, Schwarz Jürgen R, Kneussel Matthias, Fedida David, Vardanyan Vitya

Abstract excerpt

KCNQ1 potassium channels play a pivotal role in the physiology and pathophysiology of several human excitable and epithelial tissues. The latest cryo-electron microscopy (cryo-EM) structures provide unique insights into channel function and pharmacology, opening avenues for different therapeutic strategies against human diseases associated with KCNQ1 mutations. However, these structures also raise fundamental...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39671184
DOI: 10.1073/pnas.2411182121
PMCID: PMC11665860

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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