The nuclear pore complex: understanding its function through structural insight.

doi:10.1038/nrm.2016.147

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Article

The nuclear pore complex: understanding its function through structural insight.

Nature reviews. Molecular cell biology - 1 Feb 2017

Beck Martin, Hurt Ed

Abstract excerpt

Nuclear pore complexes (NPCs) fuse the inner and outer nuclear membranes to form channels across the nuclear envelope. They are large macromolecular assemblies with a complex composition and diverse functions. Apart from facilitating nucleocytoplasmic transport, NPCs are involved in chromatin organization, the regulation of gene expression and DNA repair. Understanding the molecular mechanisms underlying these...

Topics

Active Transport, Cell Nucleus
Humans
Mutation
Nuclear Pore
Nuclear Pore Complex Proteins

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Open in PubMed

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PMID: 27999437
DOI: 10.1038/nrm.2016.147

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