Article

Architecture of the linker-scaffold in the nuclear pore

2021-10-26

Abstract excerpt

The nuclear pore complex (NPC) is the sole bidirectional gateway for nucleocytoplasmic transport. Despite recent progress in elucidating the arrangement of the structured scaffold building blocks in the NPC symmetric core, their cohesion by multivalent unstructured linker proteins remained elusive. Combining biochemical reconstitution, high resolution structure determination, docking into cryo-electron tomographic...

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Literature Corpus work: 1abeacc3-9456-58e3-92fd-a342a85a86a7
DOI: 10.1101/2021.10.26.465796

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