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Article

Decoupling the dynamic mechanism revealed by FGFR2 mutation-induced population shift.

Journal of biomolecular structure & dynamics - 1 Jan 2024

Zhang Yuxiang, Yin Xiao-Lan, Ji Mingfei, Chen Yi, Chai Zongtao

Abstract excerpt

The fibroblast growth factor receptor 2 (FGFR2) is a key component in cellular signaling networks, and its dysfunctional activation has been implicated in various diseases including cancer and developmental disorders. Mutations at the activation loop (A-loop) have been suggested to trigger an increased basal kinase activity. However, the molecular mechanism underlying this highly dynamic process has not been...

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Source

Identifiers

PMID: 37254996
DOI: 10.1080/07391102.2023.2217924

Genes

FGFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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