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Article

Structure-functional prediction and analysis of cancer mutation effects in protein kinases.

Computational and mathematical methods in medicine - 1 Jan 2014

Dixit Anshuman, Verkhivker Gennady M

Abstract excerpt

A central goal of cancer research is to discover and characterize the functional effects of mutated genes that contribute to tumorigenesis. In this study, we provide a detailed structural classification and analysis of functional dynamics for members of protein kinase families that are known to harbor cancer mutations. We also present a systematic computational analysis that combines sequence and structure-based...

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Identifiers

PMID: 24817905
DOI: 10.1155/2014/653487
PMCID: PMC4000980

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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