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Article

Intrinsically active MEK variants are differentially regulated by proteinases and phosphatases.

Scientific reports - 7 Aug 2018

Ordan Merav, Pallara Chiara, Maik-Rachline Galia, Hanoch Tamar, Gervasio Francesco Luigi, Glaser Fabian, Fernandez-Recio Juan, Seger Rony

Abstract excerpt

MAPK/ERK kinase (MEK) 1/2 are central signaling proteins that serve as specificity determinants of the MAPK/ERK cascade. More than twenty activating mutations have been reported for MEK1/2, and many of them are known to cause diseases such as cancers, arteriovenous malformation and RASopathies. Changes in their intrinsic activity do not seem to correlate with the severity of the diseases. Here we studied four...

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Identifiers

PMID: 30087384
DOI: 10.1038/s41598-018-30202-5
PMCID: PMC6081382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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