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Article

Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway.

BMC systems biology - 5 Oct 2009

Orton Richard J, Adriaens Michiel E, Gormand Amelie, Sturm Oliver E, Kolch Walter, Gilbert David R

Abstract excerpt

BACKGROUND: The Epidermal Growth Factor Receptor (EGFR) activated Extracellular-signal Regulated Kinase (ERK) pathway is a critical cell signalling pathway that relays the signal for a cell to proliferate from the plasma membrane to the nucleus. Deregulation of the EGFR/ERK pathway due to alterations affecting the expression or function of a number of pathway components has long been associated with numerous...

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Identifiers

PMID: 19804630
DOI: 10.1186/1752-0509-3-100
PMCID: PMC2764635

Genes

EGFR
EGF
NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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