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Article

Oncogenic potential is related to activating effect of cancer single and double somatic mutations in receptor tyrosine kinases.

Human mutation - 1 Nov 2012

Hashimoto Kosuke, Rogozin Igor B, Panchenko Anna R

Abstract excerpt

Aberrant activation of receptor tyrosine kinases (RTKs) is a common feature of many cancer cells. It was previously suggested that the mechanisms of kinase activation in cancer might be linked to transitions between active and inactive states. Here, we estimate the effects of single and double cancer mutations on the stability of active and inactive states of the kinase domains from different RTKs. We show that...

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Source

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Identifiers

PMID: 22753356
DOI: 10.1002/humu.22145
PMCID: PMC3465464

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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