Article

Enhanced Medullary and Extramedullary Granulopoiesis Sustain the Inflammatory Response in Lupus Nephritis

2023-06-13

Abstract excerpt

<title>Abstract</title> <p>In order to meet the increased demand for effector cells in the periphery, systemic inflammation promotes medullary and extramedullary myelopoiesis. Extramedullary hematopoiesis (EMH) is emerging as a key player for tissue injury in systemic autoimmune disorders. In Systemic Lupus Erythematosus (SLE), deregulation of hematopoiesis is characterized by myeloid skewing and trained immunity...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9156de22-3131-5afa-af83-5db35fc2e545
DOI: 10.21203/rs.3.rs-3008957/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Enhanced Medullary and Extramedullary Granulopoiesis Sustain the Inflammatory Response in Lupus NephritisDOI 10.21203/rs.3.rs-3008957/v1Read

Transcriptome reprogramming and myeloid skewing in haematopoietic stem and progenitor cells in systemic lupus erythematosusSemantic proximity Read

Splenic extramedullary granulopoiesis and tissue microenvironments shape functionally distinct neutrophil subsets in autoimmunitySemantic proximity Read

Forged in the fire: Lasting impacts of inflammation on hematopoietic progenitorsSemantic proximity Read

Patrolling human SLE haematopoietic progenitors demonstrate enhanced extramedullary colonisation; implications for peripheral tissue injurySemantic proximity Read

Deep profiling of lupus nephritis kidneys reveals dynamic changes in myeloid cells associated with disease progressionSemantic proximity Read

Hematopoietic stem cells are a reservoir for trained immunity in autoimmune diseaseSemantic proximity Read

The immune cell landscape in kidneys of lupus nephritis patientsSemantic proximity Read

HSCs and Tregs cooperate to preserve extramedullary hematopoiesis under chronic inflammationSemantic proximity Read

CD8 T lymphocytes infiltrate the kidneys and correlate with disease progression in B6. <i>NZMSle1/Sle2/Sle3</i> lupus miceSemantic proximity Read

Intrarenal myeloid subsets associated with kidney injury are comparable in mice and patients with lupus nephritisSemantic proximity Read

Trained Immunity Affecting Dendritic Cell Differentiation and Function in Rheumatoid ArthritisSemantic proximity Read

Prednisone Reprograms the Transcriptional Immune Cell Landscape in CNS Autoimmune DiseaseSemantic proximity Read