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HSCs and Tregs cooperate to preserve extramedullary hematopoiesis under chronic inflammation

2025-02-08

Abstract excerpt

Hematopoietic stem cells (HSCs) are localized within specialized niches of the bone marrow (BM). However, during hematological disorders or infections, the functionality of HSCs in the BM is compromised, leading to extramedullary hematopoiesis (EMH). Chronic inflammation drives EMH, yet its impact on HSCs outside the BM is poorly understood. Using a mouse model of chronic autoinflammatory disease, we demonstrated...

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Identifiers and source

Literature Corpus work
014facda-a378-545d-9fe2-c713c27916fb
DOI
10.1101/2025.02.05.636492
Open publication

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HSCs and Tregs cooperate to preserve extramedullary hematopoiesis under chronic inflammationDOI 10.1101/2025.02.05.636492
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