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CD8 T lymphocytes infiltrate the kidneys and correlate with disease progression in B6. <i>NZMSle1/Sle2/Sle3</i> lupus mice

2025-11-04

Abstract excerpt

<h4>Background</h4> Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE) characterized by immune-mediated renal damage. While intrarenal CD8 + T cell infiltration has been linked to disease activity in patients, their pathogenic contribution remains unclear, partly due to the lack of mechanistic insight from murine models. <h4>Methods</h4> We investigated renal CD8 + T cell inf...

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Literature Corpus work
3ffcc50e-6fe2-550f-9965-90554be49439
DOI
10.1101/2025.11.03.685164
Open publication

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CD8 T lymphocytes infiltrate the kidneys and correlate with disease progression in B6. <i>NZMSle1/Sle2/Sle3</i> lupus miceDOI 10.1101/2025.11.03.685164
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