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Forged in the fire: Lasting impacts of inflammation on hematopoietic progenitors

4 Apr 2024

Abstract excerpt

Quiescence and differentiation of hematopoietic stem and progenitor cells (HSPC) can be modified by systemic inflammatory cues. Such cues can not only yield short-term changes in HSPCs such as in supporting emergency granulopoiesis but can also promote lasting influences on the HSPC compartment. First, inflammation can be a driver for clonal expansion, promoting clonal hematopoiesis for certain mutant clones,...

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PMID: 38580008
DOI: 10.1016/j.exphem.2024.104215

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