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Article

Prednisone Reprograms the Transcriptional Immune Cell Landscape in CNS Autoimmune Disease

13 Aug 2021

Abstract excerpt

Glucocorticoids (GCs) are widely used immunosuppressive drugs for autoimmune diseases, although considerable gaps exist between current knowledge of the mechanisms of GCs and their conclusive immune-regulatory effects. Here we generated a single-cell transcriptional immune cell atlas based on prednisone-treated or untreated experimental autoimmune uveitis (EAU) mice. Immune cells were globally activated in EAU,...

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PMID: 34484247
DOI: 10.3389/fimmu.2021.739605

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