Article

Splenic extramedullary granulopoiesis and tissue microenvironments shape functionally distinct neutrophil subsets in autoimmunity

2026-03-18

Abstract excerpt

<title>Abstract</title> <p> Neutrophils are increasingly recognized as key regulators of autoimmune responses and exhibit substantial functional diversity. However, the understanding of neutrophil heterogeneity in autoimmune diseases remains limited. Here, using experimental autoimmune encephalomyelitis (EAE), we identify three morphologically and transcriptionally distinct neutrophil subsets with tissue-specifi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bcd8380e-6365-5cb7-ab06-2e120a3dbfd7
DOI: 10.21203/rs.3.rs-9122986/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Splenic extramedullary granulopoiesis and tissue microenvironments shape functionally distinct neutrophil subsets in autoimmunityDOI 10.21203/rs.3.rs-9122986/v1Read

Neutrophil single-cell analysis identifies a uniquely primed subset and provides insights into predicting relapse of autoimmune small vessel vasculitisSemantic proximity Read

Alternatively activated neutrophils limit T cell–driven neuroinflammationSemantic proximity Read

Single-cell transcriptome profiling reveals neutrophil heterogeneity and orchestrated maturation during homeostasis and bacterial infectionSemantic proximity Read

Enhanced Medullary and Extramedullary Granulopoiesis Sustain the Inflammatory Response in Lupus NephritisSemantic proximity Read

Neutrophil heterogeneity and fate in inflamed tissues: implications for the resolution of inflammation.Semantic proximity Read

Single-Cell RNA Sequencing Uncovers Neutrophil Clusters Associated with Autoimmune NeuroinflammationSemantic proximity Read

Liver-specific T regulatory type-1 cells program local neutrophils to suppress hepatic autoimmunity via CRAMP.Semantic proximity Read

Distinct Functional States of Neutrophils by Actin Disassembly and NF-kB/STAT3 SignalingSemantic proximity Read

Epigenomic and functional dynamics of human bone marrow myeloid differentiation to mature blood neutrophilsSemantic proximity Read

Low-density granulocytes: a distinct class of neutrophils in systemic autoimmunitySemantic proximity Read

The journey of neutropoiesis: how complex landscapes in bone marrow guide continuous neutrophil lineage determinationSemantic proximity Read

Aging and interferon gamma response drive the phenotype of neutrophils in the inflamed jointSemantic proximity Read