Article

An anaphase surveillance mechanism prevents micronuclei formation from mitotic errors

2021-02-26

Abstract excerpt

<h4>Summary</h4> Micronuclei are a hallmark of cancer and other human disorders and have recently been implicated in chromothripsis, a series of massive genomic rearrangements that may drive tumor evolution and progression. Here we show that Aurora B kinase mediates a surveillance mechanism that integrates error correction during anaphase with spatial control of nuclear envelope reformation to protect against mic...

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Literature Corpus work: bfcf28ad-ec08-5635-8a8c-0cc9fa111173
DOI: 10.1101/2021.02.26.433009

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