Article

Preclinical Efficacy of Tasquinimod in Myelodysplastic Neoplasms: Restoring Erythropoiesis and Mitigating Bone Loss

2025-07-03

Abstract excerpt

Myelodysplastic neoplasms (MDS) are clonal disorders characterized by ineffective hematopoiesis, dysplasia, and a risk of transformation into acute myeloid leukemia. MDS is also associated with a higher incidence of osteoporosis, suggesting a complex interplay between hematopoiesis, the bone marrow (BM) microenvironment, and bone homeostasis. Targeting inflammation has emerged as a promising therapeutic strategy,...

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Literature Corpus work: 906bf391-12da-5c12-a7a9-9fcfd2ec419b
DOI: 10.1101/2025.07.01.660147

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