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Article

Success in bone marrow failure? Novel therapeutic directions based on the immune environment of myelodysplastic syndromes.

Journal of leukocyte biology - 1 Aug 2017

Cull Alyssa H, Rauh Michael J

Abstract excerpt

Myelodysplastic syndromes (MDS) are clonal neoplasms of aging that are associated with BM failure, related cytopenias, fatigue, susceptibility to infections, bruising, bleeding, a shortened lifespan, and a propensity for leukemic transformation. Most frail, elderly patients are not candidates for curative allogeneic BM transplantations and instead receive expectant management, supportive blood transfusions, or...

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Identifiers

PMID: 28596252
DOI: 10.1189/jlb.5RI0317-083R

Genes

TET2
NLRP3
TLR4

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